As Disintegrating agent: Kyron T has a very high swelling tendency of hydration either in contact with water or G.I. fluids causing fast disintegration without. Article | The purpose of present study was to compare Kyron T with other superdisintegrants and optimize the fast dissolving tablet of. industry to mask the taste of bitter medicine to achieve stability and drugs. It is white to off white fine powder, swellable in water. KYRON T is derived from.
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The purpose of this investigation was to develop mouth dissolving tablets of aceclofenac using KYRON T Polacrillin Potassium as a novel superdisintegrant.
Hardness of the tablet, which is the force applied across the diameter of the tablet to break a tablet into halves, was measured using a Pfizer tablet hardness tester. A piece of tissue paper folded twice was placed in a small petridish i. In order to describe the kinetics of the release process of drug in all the prepared formulations, zero-order and first-order rate equations were used.
Ten tablets were weighed and pulverized to a fine powder. Article Tools Print this article.
Co-processed excipients exhibited improved functionality as compared to their physical mixtures [ 7 ]. View Contact Call Seller Now. Disintegrant Excipient Tablet computer Compliance behavior.
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A total of thirteen formulations were designed and evaluated including control formulation without superdisintegrants and also compared with the marketed preparation Table 2. For the measurement of angle of repose, a glass funnel was secured with its tip kyyron a given height h above a piece of graph paper placed on a horizontal surface.
The tapped density was determined as the ratio of weight to the volume of sample after tapping a measuring cylinder for times on an Electrolab Tap density tester.
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Required quantity is from 2. Granulation procedure Tablet Dosage Form.
Table 4 and 5 depicts all the tablet parameters evaluated. PatelAvani F. Disintegration time is of much importance in formulation kyrno melt-inmouth tablets which was found to be in the range of 5.
Melt-in-mouth tablets each containing 10 mg of metoclopramide hydrochloride were prepared by direct compression method employing crospovidone, Kyron T, physical blend and co-processed mixture of both the superdisintegrants in different ratios ktron Dietary Potassium Search for additional papers on this topic.
The prepared tablets were evaluated for physical parameters such as hardness, thickness, diameter, friability, weight variation, in vitro dispersion time, in vitro disintegration time, wetting time and water absorption ratio. The standardized formulation F-X was compared with commercial conventional marketed tablets for percentage metoclopramide hydrochloride dissolved.
Subscribe to our Newsletter All our latest content delivered to kyeon inbox. Since mechanical integrity is of paramount importance in successful formulation of melt-in-mouth tablets, the hardness of the tablets was found to be in the range of 3. The thickness of the prepared tablets was found to be in the range t-14 3. Get Best Price Request a quote. Our entire range of products possess features like high water resistance, excellent adhesion properties, high elasticity, easy maintenance and smooth finishing.
At a predetermined time interval, 5 ml samples were withdrawn, filtered through a 0. The reasons for selection of crospovidone are high capillary activity, pronounced hydration capacity and little tendency t-34 form gels. Mouth dissolving tablets of aceclofenac were prepared by wet granulation technique using KYRON T as superdisintegrant and menthol as subliming agent.
Nature of Business Exporter. FTIR spectra of the crospovidone, Kyron T, physical blend and co-processed mixture of superdisintegrants in ratio of 1: College of Pharmacy, Chandwad Nasik India.
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